Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a joint strike against an subterranean weapons facility in Syrian territory operated by the IS group, as stated by the British defence ministry.
The location, pinpointed through reconnaissance, was believed to be housing weapons and explosive materials, the release indicated, and was situated in hills just north of Palmyra in the heart of Syria.
"Our fighter planes utilized laser-guided Paveway IV weapons to target a number of approach shafts providing entry to the depot... early reports indicate the strike was effective," the MoD said.
There was no indication of any civilian impact in the strike on Saturday evening and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were backed up by a Voyager refuelling tanker.
The Islamic State group - referred to as Daesh - enforced extremist governance over large swathes of Iraq and Syria before its territorial defeat in 2019.
"This strike shows the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to eliminate any re-emergence of the terrorist group and their harmful and extremist ideologies in the area," Britain's Defence Chief the minister stated.
British military aircraft have conducted overwatch operations over Syria to "forestall any attempted resurgence" of Islamic State subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank every member of our armed forces involved in this mission for their expertise and their courage," he added. "They were part of a great many UK service members deployed over the holidays. This action, to eliminate dangerous terrorists who threaten our safety, demonstrates how UK forces are ready to step up, continuously, protecting the UK at home and strong abroad."
During December, the United States armed forces carried out what it termed a "major assault" on Islamic State objectives in Syria, subsequent to an attack killed two US servicemembers and a civilian interpreter in the Palmyra area.
The U.N. says IS still has an estimated 5,000 to 7,000 combatants in Syria and Iraq.